L-Methylfolate, calcium
L-5-Methyltetrahydrofolate calcium
CAS: 151533-22-1
Molecular Formula: C20H27CaN7O6
L-Methylfolate, calcium - Names and Identifiers
| Name | L-5-Methyltetrahydrofolate calcium |
| Synonyms | L-5-MTHF-Ca Calcium levomefolate L-5- Methyl leucovorin L-Methylfolate, calcium CALCIUML-5-METHYLTETRAHYDROFOLATE L-5-Methyltetrahydrofolate calcium L-5-Methyltetrahydrofolate calcium L-Methyltetrahydrofolate, calcium salt METHYL FOLATE CALCIUM SALT(METAFOLIN)(P) L-5-Methyltetrahydrofolic acid, calcium salt Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino (S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt |
| CAS | 151533-22-1 |
| EINECS | 691-636-3 |
| InChI | InChI=1/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);/q;+2/p-2/t12-,13-;/m0./s1 |
L-Methylfolate, calcium - Physico-chemical Properties
| Molecular Formula | C20H27CaN7O6 |
| Molar Mass | 501.56 |
| Melting Point | >300°C |
| Solubility | Aqueous Acid (Heated), Water (Slightly, Heated) |
| Appearance | Solid |
| Color | Off-White to Light Yellow |
| Storage Condition | Inert atmosphere,2-8°C |
L-Methylfolate, calcium - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
L-Methylfolate, calcium - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.01 ml | 10.05 ml | 20.1 ml |
| 5 mM | 0.402 ml | 2.01 ml | 4.02 ml |
| 10 mM | 0.201 ml | 1.005 ml | 2.01 ml |
| 5 mM | 0.04 ml | 0.201 ml | 0.402 ml |
Last Update：2024-01-02 23:10:35
L-Methylfolate, calcium - Reference Information
| introduction | this product is a calcium salt of L-5-methyltetrahydrofolic acid, which belongs to folic acid family vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid. l-5-methyltetrahydrofolate calcium (5-mthf) is a naturally occurring salt-forming methyl derivative form of folic acid. 5-mthf is also called L-methylfolic acid. It is the most biologically active and functional form of folic acid and is easier to absorb than ordinary folic acid. |
| function | lack of folic acid will reduce the ability of cells to synthesize and repair DNA. folic acid supplementation may be a more favorable method to increase folic acid to reduce homocysteine levels and support normal cell proliferation and vascular endothelial function. Cardiovascular diseases, nervous system function, especially 5-MTHF supplementation during pregnancy have been shown to reduce the risk of neural tube defects and recurrence. |
| Metabolic pathway | The two main metabolic pathways that ordinary folic acid must be converted to l-type methylfolic acid to participate in: methylation process and dna synthesis, which usually appear in human plasma and The only form of free folic acid in cells is 5-mthf. Lack of folic acid is usually due to insufficient absorption due to vitamin deficiency. During pregnancy and breastfeeding, the need for folic acid is increased during the growth of children. Under the influence of absorption or metabolic changes or drugs, the dosage provided by eating folic acid-rich foods cannot be guaranteed, so it needs to be given. supplement. |
| Mechanism of Action | Bioactive folic acid in biochemical pathway involves a series of enzymatic reactions and cofactors. Absorbed folic acid is reduced and methylated to 5-MTHF during the metabolism of intestinal mucosal cells over . This transition is limited and does not alter the presence of folic acid in the blood circulation, and the dialine is subsequently converted to s adenosylmethionine (SAMe), a methyl donor involved in a number of biochemical processes. It can also be used as a donor to participate in the synthesis of nucleotides and support biosynthetic DNA. |
| biological activity | Levomefolate calcium is an artificial form of folic acid and has an anti-folic acid effect. |
Last Update：2024-04-09 20:52:54
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